abstract：BACKGROUND:Current blood transfusion standards in Canada and the United States permit transfusion of ABO-nonidentical platelets when ABO-identical platelets are not available. This practice increases the availability of platelets, a component in chronic shortage in Ontario, Canada because of the 5-day shelf-life. The i...

journal_title：Transfusion

authors： Lin Y,Callum JL,Coovadia AS,Murphy PM

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:A high-throughput detection system was developed for HBV DNA and HCV RNA. METHODS:A combination of real-time detection PCR using an automated system (PRISM 7700, PE Biosystems, Foster City, CA) and automatic viral nucleic acid extraction (BioRobot 9604, Qiagen, Hilden, Germany) was used as the high-throughp...

journal_title：Transfusion

authors： Mitsunaga S,Fujimura K,Matsumoto C,Shiozawa R,Hirakawa S,Nakajima K,Tadokoro K,Juji T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The clinical significance of alloimmunization to RBC antigens in sickle cell patients was analyzed by a retrospective review of the records of pediatric and adult sickle cell patients who received transfusions and who were followed over a 10-year period. STUDY DESIGN AND METHODS:Charts of pediatric and adul...

journal_title：Transfusion

authors： Aygun B,Padmanabhan S,Paley C,Chandrasekaran V

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Blood component irradiation is an accepted method of preventing transfusion-associated GVHD. Previous publications have largely focused on the technical aspects of the irradiation process itself, but relatively little attention has been paid to the details associated with the implementation of a blood irradi...

journal_title：Transfusion

authors： Patton GA,Skowronski MG

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Photodynamic virus inactivation of plasma with methylene blue significantly decreases the recovery of fibrinogen and coagulation factors V and VIII. Because an adequate supply of fibrinogen is essential for the therapeutic efficacy of transfused plasma in many clinical settings, it was plausible that transfu...

journal_title：Transfusion

authors： Atance R,Pereira A,Ramírez B

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Blood banks ensure the safety of blood components by testing them for a set of known infectious agents and by careful selection of donors based on a self-administered questionnaire and an interview. The purpose of this study is to describe the risk behavior for sexually transmitted diseases in Norwegian bloo...

journal_title：Transfusion

authors： Stigum H,Bosnes V,Ørjasaeter H,Heier HE,Magnus P

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Platelet transfusion-associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin-resistant Staphylococcus aureus (MRSA) is reported. CASE REPORT:A 54-year-old man, terminally ill with progressive non-H...

journal_title：Transfusion

authors： Sapatnekar S,Wood EM,Miller JP,Jacobs MR,Arduino MJ,McAllister SK,Kellum ME,Roth V,Yomtovian R

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:A novel apheresis procedure for a blood separator (MCS+, Haemonetics) enables the collection of 2 WBC-reduced RBC units in a single donation by using one disposable set with one in-line WBC-reduction filter (RC2H, Pall Corp.). The objective of this study was to evaluate the filtration performance in connecti...

journal_title：Transfusion

authors： Bandarenko N,Rose M,Kowalsky RJ,Baston RK,Brecher ME,Elfath MD,Whitley P,Heminway M,Holme S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Tissue hypoxia and reperfusion induce abnormal hemostatic function. Therefore, bleeding after total knee replacement (TKR) may be a result of a tourniquet-induced imbalance of the procoagulant and fibrinolytic systems. Because laboratory confirmation of tourniquet-induced abnormal hemostasis is difficult to ...

journal_title：Transfusion

authors： Zohar E,Fredman B,Ellis MH,Ifrach N,Stern A,Jedeikin R

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:RBCs modified with cyanuric chloride activated methoxy-PEG (CmPEG; 5000 Da) are less immunogenic than untreated RBCs, and their use thus may reduce the risk of alloimmunization in chronically transfused patients. STUDY DESIGN AND METHODS:To further examine the potential utility of CmPEG-RBCs, the effects of...

journal_title：Transfusion

authors： Bradley AJ,Test ST,Murad KL,Mitsuyoshi J,Scott MD

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:TT virus (TTV), a novel DNA virus, was originally thought to be transmitted by transfusion. However, nonparenteral transmission is recently suspected to be a major mode of transmission. To investigate the possibility of reinfection with TTV in multiply transfused patients and to evaluate the significance of ...

journal_title：Transfusion

authors： Toyoda H,Fukuda Y,Nakano I,Katano Y,Yokozaki S,Hayashi K,Ito Y,Suzuki K,Nakano H,Saito H,Takamatsu J

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Experimental studies have revealed that gelatin and HES produce increased neutrophil respiratory burst activity. It was investigated whether 3-percent gelatin (MW 35,000) and three types of 6-percent HES (MW 70,000; degree of substitution, 0.5; 200,000/0.5; 450,000/0.7) preparations can influence superoxide ...

journal_title：Transfusion

authors： Jaeger K,Heine J,Ruschulte H,Jüttner B,Scheinichen D,Kuse ER,Piepenbrock S

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Febrile nonhemolytic transfusion reaction (FNHTR) has been identified as a pivotal reason for prestorage universal WBC reduction. A regional blood center implemented universal prestorage WBC reduction for RBCs on January 1, 2000. Whether prestorage universal WBC reduction of RBC units will affect FNHTR is no...

journal_title：Transfusion

authors： Uhlmann EJ,Isgriggs E,Wallhermfechtel M,Goodnough LT

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:The use of a platelet additive solution (PAS-II, Baxter) may have benefits over plasma for storage of platelets. It was the aim of this study to develop a method to produce WBC-reduced platelet concentrates (PCs) in PAS-II with >240 x 10(9) platelets and <1 x 10(6) WBCs per unit, which can be stored for 5 da...

journal_title：Transfusion

authors： van der Meer PF,Pietersz RN,Tiekstra MJ,Huijgens PC,Dekker WJ,Reesink HW

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Selection of CD34+ PBPCs has been applied as a method of reducing graft contamination from neoplastic cells. This procedure seems to delay lymphocyte recovery, while myeloid engraftment is no different from that with unselected PBPC transplants. STUDY DESIGN AND METHODS:Lymphocyte recovery was studied in tw...

journal_title：Transfusion

authors： Laurenti L,Sorà F,Piccirillo N,Chiusolo P,Cicconi S,Rutella S,Serafini R,Garzia MG,Leone G,Sica S

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Donor WBCs are responsible for numerous transfusion complications, but little is known concerning the natural history of their clearance following transfusion or of their function in the recipient's circulation. A murine transfusion model was developed to investigate the effects of blood component characteri...

journal_title：Transfusion

authors： Lee TH,Reed W,Mangawang-Montalvo L,Watson J,Busch MP

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Monitoring blood transfusion for overutilization is standard practice at most institutions. STUDY DESIGN AND METHODS:This study monitored for underutilization of blood transfusion over a 14-month period, by evaluating patients who had Hb levels that were reported to be <5 g per dL or platelet counts <10 x 1...

journal_title：Transfusion

authors： Saxena S,Wehrli G,Makarewicz K,Sartorelli J,Shulman IA

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The addition of an appropriate metal chelator, such as diethylenetriaminopentaacetic acid (DTPA) to stored blood has been shown to be effective in a short-term (0-12 days) prevention of lipid peroxidation of stored RBCS: However, its long-term effectiveness has not been carefully evaluated. STUDY DESIGN AND...

journal_title：Transfusion

authors： Liu TZ,Chiu DT,Stern A

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:In cases of warm autoimmune hemolytic anemia (WAIHA), crossmatch incompatible RBCs are most often used for transfusion. The determination of the in vivo survival of transfused and autologous RBCs in WAIHA is helpful in the assessment of the efficacy of transfusion and other therapeutic interventions. CASE R...

journal_title：Transfusion

authors： Zeiler T,Müller JT,Hasse C,Kullmer J,Kretschmer V

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:With changing demographics of the United States population and the continuous need to recruit new donors, it is important to monitor the demographic profile of first-time donors and to evaluate changes in the donor pool to improve recruitment targeting. STUDY DESIGN AND METHODS:First-time whole blood (n = 9...

journal_title：Transfusion

authors： Wu Y,Glynn SA,Schreiber GB,Wright DJ,Lo A,Murphy EL,Kleinman SH,Garratty G,Retrovirus Epidemiology Donor Study (REDS) Group.

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:With the implementation of universal WBC reduction in the United Kingdom, in-process WBC-reduction filters for pooled buffy coat (BC)-derived platelet concentrates (PCs) are used in routine production. The effects of three filter/storage bag combinations on platelet activation and microvesiculation and on th...

journal_title：Transfusion

authors： Krailadsiri P,Seghatchian J,Williamson LM

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Recombinant human G-CSF is widely used to mobilize PBPCs in healthy donors for allogeneic transplantation. There have been concerns about donor safety because of splenic ruptures during G-CSF application. To address this problem, changes in splenic size in 91 healthy donors during G-CSF mobilization of allog...

journal_title：Transfusion

authors： Platzbecker U,Prange-Krex G,Bornhäuser M,Koch R,Soucek S,Aikele P,Haack A,Haag C,Schuler U,Berndt A,Rutt C,Ehninger G,Hölig K

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Virus inactivation of plasma can be achieved by photodynamic methods in the presence of phenothiazine dyes such as methylene blue (MB). Subsequent filtration may increase the efficacy of virus inactivation and reduce adverse effects of WBC contamination and MB. STUDY DESIGN AND METHODS:This study examined t...

journal_title：Transfusion

authors： Riggert J,Humpe A,Legler TJ,Wolf C,Simson G,Köhler M

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Patients with autoimmune lymphoproliferative syndrome (ALPS) have an autosomal dominant genetic defect that affects lymphocyte apoptosis and is associated with chronic nonmalignant lymphadenopathy, splenomegaly, and autoimmunity, particularly affecting RBCs, WBCs, and platelets. STUDY DESIGN AND METHODS:DAT...

journal_title：Transfusion

authors： Stroncek DF,Carter LB,Procter JL,Dale JK,Straus SE

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Senescent RBCs bear IgG and C3 opsonins that are three to four times less than required for similar phagocytosis of experimentally opsonized RBCs. STUDY DESIGN AND METHODS:Studies were performed to determine the phagocyte receptors involved in phagocytosis in vitro. The effect of clustering of opsonins and ...

journal_title：Transfusion

authors： Tartakover-Matalon S,Shoham-Kessary H,Foltyn V,Gershon H

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:By regulation, ongoing process control of WBC-reduced processes is performed on 1 percent of WBC-reduced components, typically four to five samples per month. However, prospective study of the power of this small sample has been difficult. Using computer-generated "residual WBC" distributions, sample size se...

journal_title：Transfusion

authors： Adams MR,Fisher DM,Dumont LJ,Dzik WH,Heaton WA

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The FcgammaRIIA gene is expressed in two polymorphic forms, R131 and H131, which differ by the replacement of histidine by arginine at position 131. The FCGR3B (FcgammaRIIIB) gene exists in two allelic isoforms, known as FCGR3B1 (FcgammaRIIIB-NA1) and FCGR3B2 (FcgammaRIIIB-NA2), which differ in nucleotides 1...

journal_title：Transfusion

authors： Kuwano ST,Bordin JO,Chiba AK,Mello AB,Figueiredo MS,Vieira-Filho JP,Fabron A Jr,Kerbauy J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:All studied photosensitizers for virus inactivation impair RBCs. To reduce damage to the RBCs without affecting virucidal activity, selective protection of the RBCs is necessary. The ability of the band 3 ligand, dipyridamole, to react with singlet oxygen and to increase the selectivity of photosterilization...

journal_title：Transfusion

authors： vanSteveninck J,Trannoy LL,Besselink GA,Dubbelman TM,Brand A,de Korte D,Verhoeven AJ,Lagerberg JW

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The use of blood-saving techniques in elective surgery can produce a favorable cost-benefit ratio only when there is a reasonable likelihood that transfusion will be required. To apply a targeted blood-sparing technique in lung cancer surgery, the patient's preoperative characteristics that predict the use o...

journal_title：Transfusion

authors： Cirasino L,Barosi G,Torre M,Crespi S,Colombo P,Belloni PA

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:The potential hemostatic effect of infusible platelet membranes (IPM; Cyplex, Cypress Bioscience) prepared from outdated human platelets is investigated. STUDY DESIGN AND METHODS:Increasing concentrations of IPM were added to blood samples anticoagulated with low-molecular-weight heparin, in which platelets...

journal_title：Transfusion

authors： Galán AM,Bozzo J,Hernández MR,Pino M,Reverter JC,Mazzara R,Escolar G,Ordinas A

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:This study explored the effect of storing packed RBCs suspended in 200 mL of an alkaline, hypotonic, experimental additive solution (EAS 61). STUDY DESIGN AND METHODS:Packed RBC units prepared from RBCs collected from healthy donors in CPD were stored for 8 (n = 10) and 9 (n = 10) weeks under blood bank con...

journal_title：Transfusion

authors： Hess JR,Rugg N,Knapp AD,Gormas JF,Silberstein EB,Greenwalt TJ

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:After multiple transfusions, the serologic typing of autologous blood group phenotypes is difficult, because of mixed RBC populations. The genotyping of ABO, Rh, Kell, Kidd, and Duffy systems could be used to determine autologous blood group antigen status. STUDY DESIGN AND METHODS:Blood samples from patien...

journal_title：Transfusion

authors： Rozman P,Dovc T,Gassner C

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:To estimate the impact of RBC preparations on the status of postoperative immune activation, the soluble cytokine receptors of TNFalpha (sTNF-R) and IL-2 (sIL-2R), as well as neopterin and cell-mediated lympholysis (CML), were measured. STUDY DESIGN AND METHODS:Patients undergoing strictly standardized anes...

journal_title：Transfusion

authors： Innerhofer P,Tilz G,Fuchs D,Luz G,Hobisch-Hagen P,Schobersberger W,Nussbaumer W,Lochs A,Irschick E

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:A reliable, validated method for rapidly determining HPC viability is essential for clinical cell engineering. STUDY DESIGN AND METHODS:A fluorometric cell viability assay using acridine orange and propidium iodide (AO/PI) was compared to the current standard, trypan blue (TB) exclusion. Viable cells staine...

journal_title：Transfusion

authors： Mascotti K,McCullough J,Burger SR

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:After allogeneic peripheral blood progenitor cell (PBPC) transplantation, a patient developed a severe hemolytic transfusion reaction due to passenger lymphocyte syndrome. CASE REPORT:A 50-year-old woman with secondary acute myeloid leukemia transforming from a myelodysplastic syndrome received an ABO-compa...

journal_title：Transfusion

authors： Leo A,Mytilineos J,Voso MT,Weber-Nordt R,Liebisch P,Lensing C,Schraven B

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The factors contributing to RBC agglutination are complex. The RBC cytoskeleton's participation in and contribution to this phenomenon are difficult to separate from those of the plasma membrane. Immunoreactive, cytoskeleton-free, band 3-enriched microvesicles can be generated from normal RBCs. Band 3 has be...

journal_title：Transfusion

authors： Jaime JC

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Specific subsets of peripheral blood WBCs are reservoirs for infectious agents, such as CMV and EBV, and can serve as vectors for transfusion transmission of these agents. While filter WBC reduction has been used to prevent transfusion transmission of infections, its effectiveness has not been documented for...

journal_title：Transfusion

authors： Roback JD,Bray RA,Hillyer CD

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Overproduction of beta-chemokines and genetic variations in chemokine receptors have been correlated with protection against infection by HIV-1 or slow progression to AIDS in infected individuals. STUDY DESIGN AND METHODS:The protective role of chemokines and their receptors was evaluated in a group of seve...

journal_title：Transfusion

authors： Barretina J,Blanco J,Gutiérrez A,Puig L,Altisent C,Espanol T,Caragol I,Clotet B,Esté JA

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:A new automated apheresis system has recently been reported as useful in improving peripheral blood HPC collection in adults. The aim of this study has been to verify the utility of this system (AutoPBSC, COBE BCT) for standard leukapheresis and for LVL in the pediatric setting. STUDY DESIGN AND METHODS:A p...

journal_title：Transfusion

authors： Torrabadella M,Olivé T,Ortega JJ,Massuet L

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Immunomodulatory effects of UV light have increasingly become a focus in transfusion medicine, BMT and transplantation immunology. In the transplant setting, the use of UVB radiation may reduce or abolish T-cell activation without compromising either bone marrow (BM) engraftment or graft-versus-leukemia effe...

journal_title：Transfusion

authors： Lankford KV,Mosunjac M,Hillyer CD

更新日期：2000-03-01 00:00:00